Measles Outbreak in Africa—Is There a Link to the HIV-1 Epidemic?

Measles remains an important cause of child mortality, although the numbers of measles-related deaths has decreased during the last decade [1] through childhood immunisation programmes and follow-up measles vaccine campaigns. In 2005, the World Health Organization (WHO) and the United Nations Children’s Fund (UNICEF) launched a global plan to further reduce measles mortality in the years 2006–2010 [2]. Despite these joint efforts, an increased number of large and deadly outbreaks of measles on the African continent were reported, with the most severe outbreaks in Chad, Nigeria, and Zimbabwe. The current increase in measles cases has been attributed to a failure in maintaining high measles vaccine coverage [3]. There are obviously several factors of medical and social relevance to take into consideration when trying to explain the increased measles outbreaks in Africa. In this article, our focus is to highlight the possibility of a co-existing link between the measles outbreaks and pathological features of HIV-1 infection in mothers and children, as the measles outbreaks occurred in countries with a high HIV-1 prevalence. Passively acquired maternal antibodies protect infants against measles until the time of measles vaccination, which in most developing countries is administered at 9 months of age. In 1992, an increased risk of measles before 9 months of age was reported in children born to mothers with HIV-1 [4], which was suggested to be due to lower levels of passively acquired antibodies at birth [5]. In a recent study, the level of measles antibodies were followed from 6 weeks of age until 11 months in HIV-1-infected, HIV-1-exposed non-infected (born to mothers with HIV-1 but not HIV-1 positive), and HIV1-seronegative children [6]. By 6 months of age, 91% and 83% of HIV-1-infected and HIV-1-exposed non-infected children had measles antibody levels of ,50 mIU/ mL (cut-off value for specific immune response); 42% of HIV-1-negative children, on the other hand, retained high antibody levels at 6 months. These findings confirm the previous observation [5] of low titres of maternal antibodies being transferred to infants of mothers with HIV-1. Children born to mothers with HIV-1 have a higher risk of contracting early measles independently of whether they are themselves HIV-1 infected [5]. In a study from Zambia, co-infection with HIV-1 and measles in children was shown to more than double the risk of death in measles during hospitalisation [7]. Deaths due to measles infection occurred in 12.2% of the children with HIV-1 (median age 12 months) as compared to 4.3% of non-HIV-1-infected children (14 months). Since the control of measles and HIV-1 relay on efficient CD8 T cell responses, the increased morbidity observed in children with HIV-1 upon measles infection can be related to the shift in cytokine profile from Th1 to Th2 occurring in these young individuals and impairing T cell responses to both pathogens [8]. A Th1 to Th2 shift during the course of chronic HIV-1 infection is associated with progression to AIDS [9], and measles virus infection also suppresses the ability of T cells to produce IL-12, thus hampering T cell responses [10]. To reduce the risk of contracting measles in areas with high HIV-1 prevalence, WHO recommended that infants receive two doses of measles vaccine, at 6 and 9 months [11]. This regimen was evaluated in Zambia [12] and results published in 2008 showed that 59% of children with HIV-1 were measles antibody positive after the first vaccine dose; this number increased to 64% after the second dose. Among HIV-1-exposed noninfected children, 68% and 94% were seropositive after the first and second immunisation, respectively, and similar figures were shown for control children (62% and 92%). To further pinpoint the B cell impairments leading to low antibody levels after measles vaccination in children with HIV-1, Nair [13] characterised early antibody responses to measles following vaccination at 9 months of age. Interestingly, HIV-1 infection impaired IgG responses after vaccination as well as the development of high avidity measles antibodies. In a study from Kenya, antibody titres to measles were evaluated 2 to 5 years after measles immunisation received during the first year of life [14]. Several years after immunisation, only 33% of the children with HIV-1 maintained measles IgG antibodies, indicating impairment in the establishment and the maintenance of serological memory responses. Which, then, could be the mechanism accounting for the decreased amount of measles antibodies circulating in mothers with HIV-1 and poor response to measles vaccination in children with HIV-1? The rapid IgM immune response towards measles occurring to a great extent in the splenic marginal zone B cells is an important first-line defence upon natural infection and after immunisation. In healthy children, the splenic marginal